Transcript: WT1-AS:13

Basic information

LNCipedia transcript ID: WT1-AS:13 
HGNC Gene Symbol: WT1-AS    
HGNC Full Gene Name: WT1 antisense RNA
Ensembl Gene ID: ENSG00000183242
Ensembl Transcript ID: ENST00000478367
Location (hg38): chr11:32437623-32438326
Strand: +
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 561 bp
Exons: 2
Sources: Ensembl release 64 - Sep 2011; Gencode v13; Ensembl release 68 - Jul 2012; NONCODE v4; Ensembl release 75 - Feb 2014; Ensembl release 83 - Dec 2015; Ensembl release 87 - Dec 2016; Ensembl release 90 - Aug 2017; Ensembl release 92 - Apr 2018
Alternative transcript names: ENST00000478367; ENST00000478367.1; WT1-AS-004; OTTHUMT00000331534.1; NONHSAT018665; ENST00000478367.5
Alternative gene names: ENSG00000183242; WT1-AS; ENSG00000183242.7; OTTHUMG00000039557.3; ENSG00000183242.11; WIT-1; WT1AS; WT1-AS1


RNA sequence:

Structure:

Protein coding potential

Metric Raw result Interpretation
PRIDE reprocessing 2.0 0 non-coding 
Lee translation initiation sites 0 non-coding 
PhyloCSF score -159.4187 non-coding 
CPAT coding probability 0.43% non-coding 
Bazzini small ORFs 0 non-coding 

In stringent set: yes

Locus conservation

Locus conservation?
WT1-AS:13 no no no no

Available literature

  1. Du (2016), Decreased expression of long non-coding RNA WT1-AS promotes cell proliferation and invasion in gastric cancer., Biochim. Biophys. Acta
  2. He (2015), LongTarget: a tool to predict lncRNA DNA-binding motifs and binding sites via Hoogsteen base-pairing analysis., Bioinformatics
  3. Jiang (2015), Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations., Oncotarget
  4. Lv (2015), WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1., J. Exp. Clin. Cancer Res.
  5. Garzon (2014), Expression and prognostic impact of lncRNAs in acute myeloid leukemia., Proc. Natl. Acad. Sci. U.S.A.
  6. Garding (2013), Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB., PLoS Genet.
  7. Dallosso (2007), Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer., RNA
  8. Hancock (2007), A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis., Hum. Mol. Genet.
  9. Dallosso (2004), Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours., Hum. Mol. Genet.
  10. Malik (2000), Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor., Cancer Res.
  11. Malik (1995), Identification of an antisense WT1 promoter in intron 1: implications for WT1 gene regulation., Oncogene
  12. Campbell (1994), Antisense transcripts and protein binding motifs within the Wilms tumour (WT1) locus., Oncogene
  13. Eccles (1994), Cloning of novel Wilms tumor gene (WT1) cDNAs; evidence for antisense transcription of WT1., Oncogene
  14. Gessler (1993), Sequence of the WT1 upstream region including the Wit-1 gene., Genomics
  15. Huang (1990), Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor., Science


LNCipedia transcript ID history

LNCipedia version LNCipedia transcript ID
1.3 lnc-EIF3M-1:5
3.1 lnc-EIF3M-2:5
4.0 WT1-AS:13
4.1 WT1-AS:13
5.0 WT1-AS:13
5.1 WT1-AS:13
5.2 WT1-AS:13