Transcript: NEAT1:6
Basic information
LNCipedia transcript ID: NEAT1:6
HGNC Gene Symbol: NEAT1
HGNC Full Gene Name:
nuclear paraspeckle assembly transcript 1
Ensembl Gene ID:
ENSG00000245532
Ensembl Transcript ID:
ENST00000501122
RefSeq ID:
NR_131012
Location (hg38): chr11:65422798-65445540
Strand: +
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 22743 bp
Exons: 1
Sources: Biogazelle lncRNA chip; Ensembl release 64 - Sep 2011; Gencode v13; Ensembl release 68 - Jul 2012; NONCODE v4; Ensembl release 75 - Feb 2014; Ensembl release 83 - Dec 2015; Ensembl release 87 - Dec 2016; Ensembl release 90 - Aug 2017; Ensembl release 92 - Apr 2018; Refseq - NCBI Annotation Release 106
Alternative transcript names: ENST00000501122; ENST00000501122.2; NEAT1-001; OTTHUMT00000389142.3; NONHSAT022112; NR_131012.1
Alternative gene names: ENSG00000245532; NEAT1; ENSG00000245532.2; OTTHUMG00000166321.3; ENSG00000245532.4; ENSG00000245532.5; TncRNA; MENepsilon/beta; LINC00084; VINC; ENSG00000245532.6; ENSG00000245532.7; ENSG00000245532.8
RNA sequence:
Structure:
Protein coding potential
| Metric |
Raw result |
Interpretation |
| PRIDE reprocessing 2.0 |
0 |
non-coding |
| Lee translation initiation sites |
1 |
non-coding |
| PhyloCSF score |
16.321 |
non-coding |
| CPAT coding probability |
5.48% |
non-coding |
| Bazzini small ORFs |
0 |
non-coding |
In stringent set:
no
Locus conservation
| Locus conservation? |
 |
 |
 |
 |
| NEAT1:6 |
no
|
no
|
no
|
no
|
Available literature
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He
(2016),
Aberrant NEAT1 expression is associated with clinical outcome in high grade glioma patients.,
APMIS
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Hu
(2016),
The plasma lncRNA acting as fingerprint in non-small-cell lung cancer.,
Tumour Biol.
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Ichigozaki
(2016),
Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma.,
Exp. Dermatol.
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Jin
(2016),
Detection of the long noncoding RNAs nuclear-enriched autosomal transcript 1 (NEAT1) and metastasis associated lung adenocarcinoma transcript 1 in the peripheral blood of HIV-1-infected patients.,
HIV Med.
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Lennox
(2016),
Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides.,
Nucleic Acids Res.
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Wilusz
(2016),
Long noncoding RNAs: Re-writing dogmas of RNA processing and stability.,
Biochim. Biophys. Acta
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Zhen
(2016),
Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axis.,
Tumour Biol.
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Barry
(2015),
Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone.,
Front Neurol
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Bhattacharyya
(2015),
The Malat1 long non-coding RNA is upregulated by signalling through the PERK axis of unfolded protein response during flavivirus infection.,
Sci Rep
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Blume
(2015),
p53-dependent non-coding RNA networks in chronic lymphocytic leukemia.,
Leukemia
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Bo
(2015),
Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.,
Oncotarget
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Budhiraja
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Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function.,
J. Virol.
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Cabili
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Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution.,
Genome Biol.
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Cajigas
(2015),
Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling.,
Development
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Carter
(2015),
Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus.,
BBA Clin
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Chen
(2015),
Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA.,
Sci Rep
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Chen
(2015),
Up regulation of the long non-coding RNA NEAT1 promotes esophageal squamous cell carcinoma cell progression and correlates with poor prognosis.,
Am J Cancer Res
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Choudhry
(2015),
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.,
Oncogene
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Dobson
(2015),
A conserved charged single α-helix with a putative steric role in paraspeckle formation.,
RNA
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Elbarbary
(2015),
CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention.,
Genes Dev.
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Giannakakis
(2015),
Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress.,
Sci Rep
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Guo
(2015),
Clinical implication of long non-coding RNA NEAT1 expression in hepatocellular carcinoma patients.,
Int J Clin Exp Pathol
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Hennig
(2015),
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.,
J. Cell Biol.
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Hu
(2015),
A common set of distinct features that characterize noncoding RNAs across multiple species.,
Nucleic Acids Res.
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Hu
(2015),
Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus.,
Genes Dev.
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Imam
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The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.,
Sci Rep
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Kawaguchi
(2015),
SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies.,
Proc. Natl. Acad. Sci. U.S.A.
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Kawaguchi
(2015),
Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies.,
Nucleus
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Lee
(2015),
The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation.,
Nucleic Acids Res.
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Li
(2015),
NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer.,
Oncotarget
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Liu
(2015),
Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells.,
J. Neurooncol.
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Oliver
(2015),
Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype.,
Cereb. Cortex
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Pan
(2015),
Upregulation and clinicopathological significance of long non-coding NEAT1 RNA in NSCLC tissues.,
Asian Pac. J. Cancer Prev.
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Pastori
(2015),
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.,
Proc. Natl. Acad. Sci. U.S.A.
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Peng
(2015),
Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression.,
J. Exp. Clin. Cancer Res.
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Persson
(2015),
Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.,
J. Allergy Clin. Immunol.
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Quek
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lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs.,
Nucleic Acids Res.
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Rice
(2015),
Roles of microRNAs and long-noncoding RNAs in human immunodeficiency virus replication.,
Wiley Interdiscip Rev RNA
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Ryan
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Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin.,
BMC Med Genomics
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Shen
(2015),
Exploration of Deregulated Long Non-Coding RNAs in Association with Hepatocarcinogenesis and Survival.,
Cancers (Basel)
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Szczepińska
(2015),
DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.,
Genome Res.
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Sørensen
(2015),
Long non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers.,
Breast Cancer Res.
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Wang
(2015),
Identification of lncRNA-associated competing triplets reveals global patterns and prognostic markers for cancer.,
Nucleic Acids Res.
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Wang
(2015),
Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma.,
PLoS ONE
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Xiao
(2015),
Predicting the functions of long noncoding RNAs using RNA-seq based on Bayesian network.,
Biomed Res Int
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Yamazaki
(2015),
The building process of the functional paraspeckle with long non-coding RNAs.,
Front Biosci (Elite Ed)
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Yin
(2015),
SnoVectors for nuclear expression of RNA.,
Nucleic Acids Res.
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Atianand
(2014),
Long non-coding RNAs and control of gene expression in the immune system.,
Trends Mol Med
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Chakravarty
(2014),
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer.,
Nat Commun
-
Cooper
(2014),
Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPARγ2 Splicing during Adipogenesis in 3T3-L1 Cells.,
Genes (Basel)
-
Gremlich
(2014),
The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development.,
Placenta
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Guallar
(2014),
RNA-binding proteins in pluripotency, differentiation, and reprogramming.,
Front Biol (Beijing)
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Hirose
(2014),
NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies.,
Mol. Biol. Cell
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Huang
(2014),
Urinary Xist is a potential biomarker for membranous nephropathy.,
Biochem. Biophys. Res. Commun.
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Ishizuka
(2014),
Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1.,
Genes Cells
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Kambara
(2014),
Negative regulation of the interferon response by an interferon-induced long non-coding RNA.,
Nucleic Acids Res.
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Li
(2014),
Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation.,
RNA Biol
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Li
(2014),
Discovery of Protein-lncRNA Interactions by Integrating Large-Scale CLIP-Seq and RNA-Seq Datasets.,
Front Bioeng Biotechnol
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Marques Howarth
(2014),
Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.,
J. Clin. Invest.
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Park
(2014),
lncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs.,
Bioinformatics
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Schmid
(2014),
SnapShot: nuclear RNAPII transcript modification.,
Cell
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Shelkovnikova
(2014),
Compromised paraspeckle formation as a pathogenic factor in FUSopathies.,
Hum. Mol. Genet.
-
Shen
(2014),
Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures.,
Nucleic Acids Res.
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Shichino
(2014),
Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1.,
Open Biol
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Standaert
(2014),
The long noncoding RNA Neat1 is required for mammary gland development and lactation.,
RNA
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Su
(2014),
Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes.,
Oncotarget
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Takahashi
(2014),
Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer.,
FEBS Open Bio
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Takahashi
(2014),
Widespread genome transcription: new possibilities for RNA therapies.,
Biochem. Biophys. Res. Commun.
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West
(2014),
The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites.,
Mol. Cell
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Xu
(2014),
Long non-coding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer.,
Medicine (Baltimore)
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Yoon
(2014),
PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity.,
Nat Commun
-
You
(2014),
MicroRNA-449a inhibits cell growth in lung cancer and regulates long noncoding RNA nuclear enriched abundant transcript 1.,
Indian J Cancer
-
Zeng
(2014),
Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells.,
BMC Cancer
-
Zhao
(2014),
Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer.,
Eur Rev Med Pharmacol Sci
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Bavarva
(2013),
Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study.,
PLoS ONE
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Chen
(2013),
Novel human lncRNA-disease association inference based on lncRNA expression profiles.,
Bioinformatics
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Dodd
(2013),
Digital quantitation of potential therapeutic target RNAs.,
Nucleic Acid Ther
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Du
(2013),
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer.,
Nat. Struct. Mol. Biol.
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Guan
(2013),
Switching cell fate, ncRNAs coming to play.,
Cell Death Dis
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Hangauer
(2013),
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs.,
PLoS Genet.
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Kapusta
(2013),
Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs.,
PLoS Genet.
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Naganuma
(2013),
Paraspeckle formation during the biogenesis of long non-coding RNAs.,
RNA Biol
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Nishimoto
(2013),
The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.,
Mol Brain
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Tang
(2013),
Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma.,
Biomed Res Int
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Wan
(2013),
Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway.,
Cell. Signal.
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Zhang
(2013),
NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression.,
MBio
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Clark
(2012),
Genome-wide analysis of long noncoding RNA stability.,
Genome Res.
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Hirose
(2012),
Paraspeckles: possible nuclear hubs by the RNA for the RNA.,
Biomol Concepts
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Ip
(2012),
Long non-coding RNAs in nuclear bodies.,
Dev. Growth Differ.
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Johnson
(2012),
Long non-coding RNAs in Huntington's disease neurodegeneration.,
Neurobiol. Dis.
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Lipovich
(2012),
Activity-dependent human brain coding/noncoding gene regulatory networks.,
Genetics
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Miyagawa
(2012),
Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles.,
RNA
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Mizutani
(2012),
Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells.,
PLoS ONE
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Naganuma
(2012),
Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles.,
EMBO J.
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Nakagawa
(2012),
Malat1 is not an essential component of nuclear speckles in mice.,
RNA
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Passon
(2012),
Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.,
Proc. Natl. Acad. Sci. U.S.A.
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Qureshi
(2012),
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease.,
Nat. Rev. Neurosci.
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Schor
(2012),
Perturbation of chromatin structure globally affects localization and recruitment of splicing factors.,
PLoS ONE
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Yin
(2012),
Long noncoding RNAs with snoRNA ends.,
Mol. Cell
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Guttman
(2011),
lincRNAs act in the circuitry controlling pluripotency and differentiation.,
Nature
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Mao
(2011),
Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.,
Nat. Cell Biol.
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Michelhaugh
(2011),
Mining Affymetrix microarray data for long non-coding RNAs: altered expression in the nucleus accumbens of heroin abusers.,
J. Neurochem.
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Nakagawa
(2011),
eXIST with matrix-associated proteins.,
Trends Cell Biol.
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Nakagawa
(2011),
Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice.,
J. Cell Biol.
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Shevtsov
(2011),
Nucleation of nuclear bodies by RNA.,
Nat. Cell Biol.
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Silva
(2011),
LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation.,
RNA Biol
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Simon
(2011),
The genomic binding sites of a noncoding RNA.,
Proc. Natl. Acad. Sci. U.S.A.
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Tollervey
(2011),
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.,
Nat. Neurosci.
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Yang
(2011),
Genomewide characterization of non-polyadenylated RNAs.,
Genome Biol.
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Zong
(2011),
RNA splicing control: yet another gene regulatory role for long nuclear noncoding RNAs.,
RNA Biol
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Mercer
(2010),
Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation.,
BMC Neurosci
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Murthy
(2010),
Identification of protein interaction regions of VINC/NEAT1/Men epsilon RNA.,
FEBS Lett.
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Souquere
(2010),
Highly ordered spatial organization of the structural long noncoding NEAT1 RNAs within paraspeckle nuclear bodies.,
Mol. Biol. Cell
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Chen
(2009),
Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.,
Mol. Cell
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Clemson
(2009),
An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.,
Mol. Cell
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Friedel
(2009),
Conserved principles of mammalian transcriptional regulation revealed by RNA half-life.,
Nucleic Acids Res.
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Sasaki
(2009),
MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles.,
Proc. Natl. Acad. Sci. U.S.A.
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MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.,
Genome Res.
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Hutchinson
(2007),
A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains.,
BMC Genomics
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Identification and characterization of a virus-inducible non-coding RNA in mouse brain.,
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LNCipedia transcript ID history
| LNCipedia version |
LNCipedia transcript ID |
| 1.3 |
lnc-FRMD8-1:3 |
| 3.1 |
lnc-AP000769.1-2:3 |
| 4.0 |
NEAT1:6 |
| 4.1 |
NEAT1:6 |
| 5.0 |
NEAT1:6 |
| 5.1 |
NEAT1:6 |
| 5.2 |
NEAT1:6 |