Transcript: GAS5:47
Basic information
LNCipedia transcript ID: GAS5:47
LNCipedia gene ID: GAS5
Location (hg38): chr1:173851285-173868952
Strand: -
Class: antisense
Sequence Ontology term: antisense_lncRNA
Transcript size: 13389 bp
Exons: 11
Sources: FANTOM CAT (stringent)
Alternative transcript names: ENSG00000234741.3|HBMT00000080837.1
Alternative gene names: SNHG2; NCRNA00030
RNA sequence:
Structure:
Protein coding potential
| Metric |
Raw result |
Interpretation |
| PRIDE reprocessing 2.0 |
0 |
non-coding |
| Lee translation initiation sites |
|
non-coding |
| PhyloCSF score |
61.4622 |
coding |
| CPAT coding probability |
0.57% |
non-coding |
| Bazzini small ORFs |
0 |
non-coding |
In stringent set:
no
Locus conservation
| Locus conservation? |
 |
 |
 |
 |
| GAS5:47 |
no
|
no
|
no
|
no
|
Available literature
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Chang
(2016),
Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin.,
Mol Med Rep
-
Fayda
(2016),
Do circulating long non-coding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy?,
Tumour Biol.
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Han
(2016),
Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects.,
Tumour Biol.
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Hu
(2016),
Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21.,
Tumour Biol.
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Ma
(2016),
The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers.,
Tumour Biol.
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Thorenoor
(2016),
Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer.,
Oncotarget
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Bo
(2015),
Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.,
Oncotarget
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Cabili
(2015),
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution.,
Genome Biol.
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Cai
(2015),
Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway.,
Onco Targets Ther
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Carter
(2015),
Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus.,
BBA Clin
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Chen
(2015),
Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity.,
Sci Rep
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Chen
(2015),
Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA.,
Sci Rep
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Dong
(2015),
The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression.,
J Hematol Oncol
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Gao
(2015),
Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway.,
Oncol. Rep.
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Ge
(2015),
MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma.,
PLoS Genet.
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Glover
(2015),
Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence.,
Endocr. Relat. Cancer
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Guo
(2015),
LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells.,
J. Biomed. Sci.
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Guo
(2015),
Competing endogenous RNA networks and gastric cancer.,
World J. Gastroenterol.
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He
(2015),
An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes.,
Nucleic Acids Res.
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Imam
(2015),
The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.,
Sci Rep
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Işın
(2015),
Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease.,
Front Genet
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Keenan
(2015),
Pro-inflammatory mediators increase levels of the noncoding RNA GAS5 in airway smooth muscle and epithelial cells.,
Can. J. Physiol. Pharmacol.
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Li
(2015),
Low expression of lncRNA-GAS5 is implicated in human primary varicose great saphenous veins.,
PLoS ONE
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Li
(2015),
Long non-coding RNA HOTTIP is up-regulated and associated with poor prognosis in patients with osteosarcoma.,
Int J Clin Exp Pathol
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Liu
(2015),
Construction of a lncRNA-PCG bipartite network and identification of cancer-related lncRNAs: a case study in prostate cancer.,
Mol Biosyst
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Liu
(2015),
Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells.,
J. Neurooncol.
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Liu
(2015),
lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer.,
Sci Rep
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Liu
(2015),
Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1.,
Int J Clin Exp Pathol
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Liu
(2015),
Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer.,
Int J Clin Exp Pathol
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Lucafo
(2015),
Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response.,
Curr. Mol. Med.
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Malouf
(2015),
Characterization of long non-coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing.,
Mol Oncol
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Na
(2015),
Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway.,
Int J Clin Exp Med
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Pastori
(2015),
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.,
Proc. Natl. Acad. Sci. U.S.A.
-
Pei
(2015),
Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5.,
Int J Clin Exp Med
-
Peng
(2015),
The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto's Thyroiditis.,
Sci Rep
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Peschansky
(2015),
Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.,
Front Genet
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Pickard
(2015),
Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA.,
Genes (Basel)
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Ragusa
(2015),
Non-coding landscapes of colorectal cancer.,
World J. Gastroenterol.
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Shi
(2015),
A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer.,
Mol. Carcinog.
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Shi
(2015),
Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis.,
Int J Clin Exp Pathol
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Sun
(2015),
Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma.,
Int J Clin Exp Pathol
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Tani
(2015),
Development of cytotoxicity-sensitive human cells using overexpression of long non-coding RNAs.,
J. Biosci. Bioeng.
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Tantai
(2015),
Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer.,
Int J Clin Exp Pathol
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Tao
(2015),
Association between indel polymorphism in the promoter region of lncRNA GAS5 and the risk of hepatocellular carcinoma.,
Carcinogenesis
-
Wang
(2015),
Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer.,
Sci Rep
-
Wang
(2015),
Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma.,
Int J Clin Exp Med
-
Wei
(2015),
Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor.,
Oncotarget
-
Wong
(2015),
Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma.,
Mol. Cancer
-
Xie
(2015),
Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression.,
Oncotarget
-
Xue
(2015),
Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma.,
Int J Clin Exp Pathol
-
Yacqub-Usman
(2015),
Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells.,
Prostate
-
Yan
(2015),
Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma.,
Int J Clin Exp Pathol
-
Yang
(2015),
High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion.,
Eur Rev Med Pharmacol Sci
-
Ye
(2015),
Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance.,
Int J Clin Exp Med
-
Yu
(2015),
Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma.,
World J. Gastroenterol.
-
Yu
(2015),
Long Non-coding RNA Growth Arrest-specific Transcript 5 (GAS5) Inhibits Liver Fibrogenesis through a Mechanism of Competing Endogenous RNA.,
J. Biol. Chem.
-
Yu
(2015),
Long non-coding RNA growth arrest-specific transcript 5 in tumor biology.,
Oncol Lett
-
Zhang
(2015),
Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma.,
PLoS ONE
-
Zhao
(2015),
Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer.,
Int J Clin Exp Pathol
-
Zhao
(2015),
Gas5 Exerts Tumor-suppressive Functions in Human Glioma Cells by Targeting miR-222.,
Mol. Ther.
-
Zhou
(2015),
Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma.,
J Genet Genomics
-
Cao
(2014),
Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer.,
Int J Clin Exp Pathol
-
Chiyomaru
(2014),
Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells.,
J. Biol. Chem.
-
DeOcesano-Pereira
(2014),
Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis.,
Nucleic Acids Res.
-
Gezer
(2014),
Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes.,
Cell Biol. Int.
-
Hu
(2014),
The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation.,
PLoS ONE
-
Hudson
(2014),
The structure, function and evolution of proteins that bind DNA and RNA.,
Nat. Rev. Mol. Cell Biol.
-
Hudson
(2014),
Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.,
Nat Commun
-
Isin
(2014),
Investigation of circulating lncRNAs in B-cell neoplasms.,
Clin. Chim. Acta
-
Krell
(2014),
Growth arrest-specific transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer.,
PLoS ONE
-
Li
(2014),
A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.,
Cancer Cell
-
Li
(2014),
A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses.,
PLoS ONE
-
Li
(2014),
Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma.,
Int J Clin Exp Pathol
-
Li
(2014),
Discovery of Protein-lncRNA Interactions by Integrating Large-Scale CLIP-Seq and RNA-Seq Datasets.,
Front Bioeng Biotechnol
-
Ma
(2014),
Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer.,
Mol. Cancer
-
Malek
(2014),
Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer.,
Oncotarget
-
Mourtada-Maarabouni
(2014),
Role of GAS5 noncoding RNA in mediating the effects of rapamycin and its analogues on mantle cell lymphoma cells.,
Clin Lymphoma Myeloma Leuk
-
Pickard
(2014),
Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy.,
Breast Cancer Res. Treat.
-
Renganathan
(2014),
GAS5 long non-coding RNA in malignant pleural mesothelioma.,
Mol. Cancer
-
Song
(2014),
A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis.,
J. Orthop. Res.
-
Su
(2014),
Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes.,
Oncotarget
-
Sun
(2014),
Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer.,
BMC Cancer
-
Tu
(2014),
Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma.,
Int J Clin Exp Pathol
-
Wang
(2014),
Exploring the stability of long intergenic non-coding RNA in K562 cells by comparative studies of RNA-Seq datasets.,
Biol. Direct
-
Xing
(2014),
Identification of long noncoding RNA associated with osteoarthritis in humans.,
Orthop Surg
-
Yin
(2014),
Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer.,
Med. Oncol.
-
You
(2014),
MicroRNA-449a inhibits cell growth in lung cancer and regulates long noncoding RNA nuclear enriched abundant transcript 1.,
Indian J Cancer
-
Zhou
(2014),
An emerging understanding of long noncoding RNAs in kidney cancer.,
J. Cancer Res. Clin. Oncol.
-
Beato
(2013),
A new role for an old player: steroid receptor RNA Activator (SRA) represses hormone inducible genes.,
Transcription
-
Cao
(2013),
Analysis of long non-coding RNA expression profiles in gastric cancer.,
World J. Gastroenterol.
-
Du
(2013),
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer.,
Nat. Struct. Mol. Biol.
-
Kapusta
(2013),
Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs.,
PLoS Genet.
-
Liu
(2013),
LncRNA loc285194 is a p53-regulated tumor suppressor.,
Nucleic Acids Res.
-
Liu
(2013),
Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6.,
PLoS ONE
-
Lu
(2013),
Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6.,
Cell Tissue Res.
-
Mourtada-Maarabouni
(2013),
Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.,
Biomed Res Int
-
Pickard
(2013),
Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines.,
Biochim. Biophys. Acta
-
Qi
(2013),
Low expression of LOC285194 is associated with poor prognosis in colorectal cancer.,
J Transl Med
-
Qiao
(2013),
Long non-coding RNA GAS5 functions as a tumor suppressor in renal cell carcinoma.,
Asian Pac. J. Cancer Prev.
-
Wan
(2013),
Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway.,
Cell. Signal.
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Zhang
(2013),
A long non-coding RNA signature in glioblastoma multiforme predicts survival.,
Neurobiol. Dis.
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Zhang
(2013),
Negative regulation of lncRNA GAS5 by miR-21.,
Cell Death Differ.
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Özgür
(2013),
Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells.,
Clin. Exp. Med.
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Mizutani
(2012),
Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells.,
PLoS ONE
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Wang
(2011),
Molecular mechanisms of long noncoding RNAs.,
Mol. Cell
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Smith
(1998),
Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes.,
Mol. Cell. Biol.
LNCipedia transcript ID history
| LNCipedia version |
LNCipedia transcript ID |
| 4.1 |
GAS5:47 |
| 5.0 |
GAS5:47 |
| 5.1 |
GAS5:47 |
| 5.2 |
GAS5:47 |