Gene: HOTTIP
Basic information
LNCipedia gene ID: HOTTIP
Location (hg38): chr7:27198575-27207259
Strand: +
Class: antisense
Sequence Ontology term: antisense_lncRNA_gene
Transcripts: 9
Transcripts
| Transcript ID | Location (hg38) | Length |
| HOTTIP:1 |
chr7:27198575-27201236 |
781 bp |
| HOTTIP:10 |
chr7:27201844-27207259 |
3343 bp |
| HOTTIP:2 |
chr7:27200421-27207259 |
4511 bp |
| HOTTIP:3 |
chr7:27200421-27207259 |
4665 bp |
| HOTTIP:4 |
chr7:27200421-27201687 |
1166 bp |
| HOTTIP:5 |
chr7:27200437-27202822 |
2285 bp |
| HOTTIP:6 |
chr7:27200437-27201823 |
1286 bp |
| HOTTIP:7 |
chr7:27201842-27207259 |
3345 bp |
| HOTTIP:8 |
chr7:27202030-27207259 |
3157 bp |
Locus conservation
| Locus conservation? |
 |
 |
 |
 |
| HOTTIP |
yes
|
no
|
no
|
no
|
Available literature
-
Lian
(2016),
The long noncoding RNA HOXA transcript at the distal tip promotes colorectal cancer growth partially via silencing of p21 expression.,
Tumour Biol.
-
Carlson
(2015),
LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes.,
PLoS Genet.
-
Chen
(2015),
Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA.,
Sci Rep
-
Cheng
(2015),
The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.,
Oncotarget
-
Deng
(2015),
Long non-coding RNA HOTTIP promotes tumor growth and inhibits cell apoptosis in lung cancer.,
Cell. Mol. Biol. (Noisy-le-grand)
-
Díaz-Beyá
(2015),
The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature.,
Oncotarget
-
Ge
(2015),
MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma.,
PLoS Genet.
-
Huang
(2015),
HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma.,
Oncotarget
-
Ji
(2015),
LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway.,
Oncotarget
-
Konermann
(2015),
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.,
Nature
-
Li
(2015),
The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer.,
J Transl Med
-
Li
(2015),
Long non-coding RNA HOTTIP is up-regulated and associated with poor prognosis in patients with osteosarcoma.,
Int J Clin Exp Pathol
-
Lü
(2015),
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation.,
Cell Death Dis
-
Nie
(2015),
Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression.,
Mol. Cancer Ther.
-
Ren
(2015),
Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer.,
Int J Clin Exp Pathol
-
Richards
(2015),
A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer.,
Oncotarget
-
Smolle
(2015),
Long Non-Coding RNAs in Endometrial Carcinoma.,
Int J Mol Sci
-
Tsang
(2015),
Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b.,
Liver Int.
-
Werner
(2015),
Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes.,
Cell Rep
-
Wongtrakoongate
(2015),
Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes.,
PLoS Genet.
-
Xiao
(2015),
Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Activating C/EBPα.,
Stem Cell Reports
-
Xie
(2015),
Long none coding RNA HOTTIP/HOXA13 act as synergistic role by decreasing cell migration and proliferation in Hirschsprung disease.,
Biochem. Biophys. Res. Commun.
-
Yang
(2015),
LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma.,
Oncotarget
-
Zhang
(2015),
Long non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma.,
Tumour Biol.
-
Chi
(2014),
Role of BC040587 as a predictor of poor outcome in breast cancer.,
Cancer Cell Int.
-
Collier
(2014),
Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet.,
J. Immunol.
-
Ding
(2014),
Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer.,
Onco Targets Ther
-
Guallar
(2014),
RNA-binding proteins in pluripotency, differentiation, and reprogramming.,
Front Biol (Beijing)
-
Li
(2014),
Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation.,
RNA Biol
-
Ounzain
(2014),
Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease.,
J. Mol. Cell. Cardiol.
-
Quagliata
(2014),
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.,
Hepatology
-
Quinn
(2014),
Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification.,
Nat. Biotechnol.
-
Quinodoz
(2014),
Long noncoding RNAs: an emerging link between gene regulation and nuclear organization.,
Trends Cell Biol.
-
Xu
(2014),
Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma.,
Int. J. Biol. Sci.
-
Yang
(2014),
Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency.,
Elife
-
You
(2014),
MicroRNA-449a inhibits cell growth in lung cancer and regulates long noncoding RNA nuclear enriched abundant transcript 1.,
Indian J Cancer
-
Batagov
(2013),
Role of genomic architecture in the expression dynamics of long noncoding RNAs during differentiation of human neuroblastoma cells.,
BMC Syst Biol
-
Du
(2013),
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer.,
Nat. Struct. Mol. Biol.
-
Hangauer
(2013),
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs.,
PLoS Genet.
-
Kim
(2013),
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.,
Oncogene
-
Kim
(2013),
Two non-coding RNAs, MicroRNA-101 and HOTTIP contribute cartilage integrity by epigenetic and homeotic regulation of integrin-α1.,
Cell. Signal.
-
Lai
(2013),
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription.,
Nature
-
Matsui
(2013),
Promoter RNA links transcriptional regulation of inflammatory pathway genes.,
Nucleic Acids Res.
-
Nie
(2013),
Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival.,
Cancer Sci.
-
Niemczyk
(2013),
Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA.,
Am. J. Hum. Genet.
-
Sauvageau
(2013),
Multiple knockout mouse models reveal lincRNAs are required for life and brain development.,
Elife
-
Zhao
(2013),
HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells.,
J. Cell. Biochem.
-
Ørom
(2013),
Long noncoding RNAs usher in a new era in the biology of enhancers.,
Cell
-
Glazko
(2012),
Computational prediction of polycomb-associated long non-coding RNAs.,
PLoS ONE
-
Jeggari
(2012),
miRcode: a map of putative microRNA target sites in the long non-coding transcriptome.,
Bioinformatics
-
Martin
(2012),
Uncovering the role of genomic "dark matter" in human disease.,
J. Clin. Invest.
-
Troy
(2012),
Genetic "lnc"-age of noncoding RNAs to human disease.,
J. Clin. Invest.
-
Vizoso
(2012),
The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy.,
Cell Res.
-
Burgess
(2011),
Non-coding RNA: HOTTIP goes the distance.,
Nat. Rev. Genet.
-
Paralkar
(2011),
A new 'Linc' between noncoding RNAs and blood development.,
Genes Dev.
-
Simon
(2011),
The genomic binding sites of a noncoding RNA.,
Proc. Natl. Acad. Sci. U.S.A.
-
Wang
(2011),
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.,
Nature
-
Wang
(2011),
Molecular mechanisms of long noncoding RNAs.,
Mol. Cell